Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 101191..101674 Replicon chromosome
Accession NZ_LR777867
Organism Corynebacterium diphtheriae isolate NCTC11397

Toxin (Protein)


Gene name relE Uniprot ID A0A806GHY4
Locus tag NCTC11397BIS_RS00555 Protein ID WP_014302726.1
Coordinates 101411..101674 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag NCTC11397BIS_RS00550 Protein ID WP_003850117.1
Coordinates 101191..101427 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCTC11397BIS_RS00525 (LRS77_RS00515) 96570..96968 + 399 WP_003850107.1 LysE family transporter -
NCTC11397BIS_RS00530 (LRS77_RS00520) 97234..97992 + 759 WP_003850109.1 hypothetical protein -
NCTC11397BIS_RS00535 (LRS77_RS00525) 98272..99120 + 849 WP_003850110.1 helix-turn-helix domain-containing protein -
NCTC11397BIS_RS00540 (LRS77_RS00530) 99042..99794 + 753 WP_227889257.1 IS30 family transposase -
NCTC11397BIS_RS00545 (LRS77_RS00535) 100005..100688 - 684 WP_014302723.1 hypothetical protein -
NCTC11397BIS_RS00550 (LRS77_RS00540) 101191..101427 + 237 WP_003850117.1 ribbon-helix-helix domain-containing protein Antitoxin
NCTC11397BIS_RS00555 (LRS77_RS00545) 101411..101674 + 264 WP_014302726.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NCTC11397BIS_RS00560 (LRS77_RS00550) 101801..102094 + 294 WP_014302727.1 RNA-binding S4 domain-containing protein -
NCTC11397BIS_RS00565 (LRS77_RS00555) 102094..102918 + 825 WP_014301205.1 VOC family protein -
NCTC11397BIS_RS00570 (LRS77_RS00560) 102924..103229 + 306 WP_003850125.1 MGMT family protein -
NCTC11397BIS_RS00575 (LRS77_RS00565) 103239..104159 - 921 WP_003850127.1 alpha/beta hydrolase -
NCTC11397BIS_RS00580 (LRS77_RS00570) 104299..104925 + 627 WP_014318472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 67205..102094 34889


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(7-43)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9911.45 Da        Isoelectric Point: 10.9201

>T289059 WP_014302726.1 NZ_LR777867:101411-101674 [Corynebacterium diphtheriae]
VAWEISFSPRAVKSFKKLDTGEQRRVSKFLREVGALEDPRLRGKALTANKSGLWRWRVGDYRIIADIVDARVVVVVVDVG
HRSKAYD

Download         Length: 264 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8911.02 Da        Isoelectric Point: 4.8604

>AT289059 WP_003850117.1 NZ_LR777867:101191-101427 [Corynebacterium diphtheriae]
MSGSVISLRIDDEQKRRLDELSRRTGRPCSFYLREALSAHLADLEYVYRLEEEAAQVRRGELGTVPLSQLERECGLGD

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806GHY4

Antitoxin

Source ID Structure

References