Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 153462..154132 | Replicon | plasmid pVIR_Kpn2166 |
Accession | NZ_LR745046 | ||
Organism | Klebsiella pneumoniae isolate Kpn2166 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | Q6U619 |
Locus tag | GWJ69_RS27020 | Protein ID | WP_004213072.1 |
Coordinates | 153462..153905 (-) | Length | 148 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | Q6U620 |
Locus tag | GWJ69_RS27025 | Protein ID | WP_004213073.1 |
Coordinates | 153902..154132 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GWJ69_RS26990 | 148867..149142 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
GWJ69_RS26995 | 149205..149696 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
GWJ69_RS27000 | 149745..150665 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
GWJ69_RS27005 | 150756..151162 | + | 407 | Protein_160 | GAF domain-containing protein | - |
GWJ69_RS28125 | 151677..152318 | - | 642 | Protein_161 | response regulator | - |
GWJ69_RS27010 | 152735..153028 | + | 294 | Protein_162 | transposase | - |
GWJ69_RS27015 | 153032..153448 | + | 417 | Protein_163 | restriction endonuclease | - |
GWJ69_RS27020 | 153462..153905 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
GWJ69_RS27025 | 153902..154132 | - | 231 | WP_004213073.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
GWJ69_RS27030 | 154740..155873 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
GWJ69_RS27035 | 155889..156182 | + | 294 | WP_004213076.1 | hypothetical protein | - |
GWJ69_RS27040 | 156172..156378 | - | 207 | WP_004213077.1 | hypothetical protein | - |
GWJ69_RS27045 | 156730..157020 | + | 291 | WP_004213078.1 | hypothetical protein | - |
GWJ69_RS27050 | 157010..157909 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | rmpA / iroN / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / rmpA / rmpA2 | 1..226671 | 226671 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T289055 WP_004213072.1 NZ_LR745046:c153905-153462 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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