289054

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 87951..88687 Replicon plasmid pVIR_Kpn2166
Accession NZ_LR745046
Organism Klebsiella pneumoniae isolate Kpn2166

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag GWJ69_RS26690 Protein ID WP_004098919.1
Coordinates 87951..88433 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7D3T1D0
Locus tag GWJ69_RS26695 Protein ID WP_004213599.1
Coordinates 88421..88687 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWJ69_RS26670 83528..84874 + 1347 WP_011154555.1 dihydroorotase -
GWJ69_RS26675 84938..85737 + 800 Protein_94 hypothetical protein -
GWJ69_RS26680 85912..86307 + 396 Protein_95 DDE-type integrase/transposase/recombinase -
GWJ69_RS26685 86303..87530 - 1228 Protein_96 IS3 family transposase -
GWJ69_RS26690 87951..88433 - 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
GWJ69_RS26695 88421..88687 - 267 WP_004213599.1 DUF1778 domain-containing protein Antitoxin
GWJ69_RS26700 88882..89112 - 231 WP_004213598.1 hypothetical protein -
GWJ69_RS26705 89126..89329 - 204 WP_004213596.1 hemolysin expression modulator Hha -
GWJ69_RS26710 89390..89884 - 495 WP_004213594.1 hypothetical protein -
GWJ69_RS26715 89926..92895 - 2970 WP_004213592.1 Tn3 family transposase -
GWJ69_RS26720 92898..93455 - 558 WP_004213590.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA / iroN / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / rmpA / rmpA2 1..226671 226671
- inside IScluster/Tn - - 86303..93455 7152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T289054 WP_004098919.1 NZ_LR745046:c88433-87951 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10151.58 Da        Isoelectric Point: 4.5141

>AT289054 WP_004213599.1 NZ_LR745046:c88687-88421 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRVLIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A7D3T1D0

References