Detailed information of TA system TA028905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2787711..2788351
• Replicon: chromosome
• Accession: NC_020245
• Organism: Mycobacterium bovis BCG str. Korea 1168P

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: K60_RS13020
• Protein ID: WP_003412970.1
• Coordinates: 2787711..2788130 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: K60_RS13025
• Protein ID: WP_003412975.1
• Coordinates: 2788127..2788351 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K60_RS12995	2783296..2784018	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
K60_RS13000	2784535..2784762	+	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
K60_RS13005	2784759..2785160	+	402	WP_003412963.1	PIN domain-containing protein	-
K60_RS13010	2785195..2786115	-	921	WP_011799273.1	restriction endonuclease	-
K60_RS22335	2786456..2786701	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
K60_RS13015	2786760..2787710	+	951	WP_003911916.1	Lsr2 family protein	-
K60_RS13020	2787711..2788130	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
K60_RS13025	2788127..2788351	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
K60_RS13030	2788382..2791225	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
K60_RS13035	2791297..2791698	-	402	WP_003412981.1	hypothetical protein	-
K60_RS13040	2791698..2792168	-	471	WP_003412985.1	transcription antitermination factor NusB	-
K60_RS13045	2792171..2792734	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T28905 WP_003412970.1 NC_020245:c2788130-2787711 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T28905 NC_020245:c2788130-2787711 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT28905 WP_003412975.1 NC_020245:c2788351-2788127 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT28905 NC_020245:c2788351-2788127 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09