289049

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4651378..4652188 Replicon chromosome
Accession NZ_LR745045
Organism Klebsiella pneumoniae isolate Kpn2166

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag GWJ69_RS22980 Protein ID WP_004178461.1
Coordinates 4651378..4651911 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag GWJ69_RS22985 Protein ID WP_002887278.1
Coordinates 4651922..4652188 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWJ69_RS22975 4650209..4651330 + 1122 WP_004214138.1 cupin domain-containing protein -
GWJ69_RS22980 4651378..4651911 - 534 WP_004178461.1 GNAT family N-acetyltransferase Toxin
GWJ69_RS22985 4651922..4652188 - 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
GWJ69_RS22990 4652291..4653724 - 1434 WP_004214141.1 Cu(+)/Ag(+) sensor histidine kinase -
GWJ69_RS22995 4653714..4654397 - 684 WP_004214143.1 copper response regulator transcription factor CusR -
GWJ69_RS23000 4654569..4655954 + 1386 WP_004214145.1 efflux transporter outer membrane subunit -
GWJ69_RS23005 4655972..4656316 + 345 WP_004214146.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T289049 WP_004178461.1 NZ_LR745045:c4651911-4651378 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT289049 WP_002887278.1 NZ_LR745045:c4652188-4651922 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References