Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4044360..4044979 | Replicon | chromosome |
Accession | NZ_LR745045 | ||
Organism | Klebsiella pneumoniae isolate Kpn2166 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | GWJ69_RS20030 | Protein ID | WP_002892050.1 |
Coordinates | 4044761..4044979 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | GWJ69_RS20025 | Protein ID | WP_002892066.1 |
Coordinates | 4044360..4044734 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GWJ69_RS20015 | 4039512..4040705 | + | 1194 | WP_004177236.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
GWJ69_RS20020 | 4040728..4043874 | + | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
GWJ69_RS20025 | 4044360..4044734 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
GWJ69_RS20030 | 4044761..4044979 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
GWJ69_RS20035 | 4045138..4045704 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
GWJ69_RS20040 | 4045676..4045816 | - | 141 | WP_004147370.1 | hypothetical protein | - |
GWJ69_RS20045 | 4045837..4046307 | + | 471 | WP_002892026.1 | YlaC family protein | - |
GWJ69_RS20050 | 4046282..4047733 | - | 1452 | WP_004213726.1 | PLP-dependent aminotransferase family protein | - |
GWJ69_RS20055 | 4047834..4048532 | + | 699 | WP_004177238.1 | GNAT family N-acetyltransferase | - |
GWJ69_RS20060 | 4048529..4048669 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
GWJ69_RS20065 | 4048669..4048932 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T289048 WP_002892050.1 NZ_LR745045:4044761-4044979 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT289048 WP_002892066.1 NZ_LR745045:4044360-4044734 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |