Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4044360..4044979 Replicon chromosome
Accession NZ_LR745045
Organism Klebsiella pneumoniae isolate Kpn2166

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GWJ69_RS20030 Protein ID WP_002892050.1
Coordinates 4044761..4044979 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GWJ69_RS20025 Protein ID WP_002892066.1
Coordinates 4044360..4044734 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWJ69_RS20015 4039512..4040705 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GWJ69_RS20020 4040728..4043874 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GWJ69_RS20025 4044360..4044734 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GWJ69_RS20030 4044761..4044979 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GWJ69_RS20035 4045138..4045704 + 567 WP_002892030.1 maltose O-acetyltransferase -
GWJ69_RS20040 4045676..4045816 - 141 WP_004147370.1 hypothetical protein -
GWJ69_RS20045 4045837..4046307 + 471 WP_002892026.1 YlaC family protein -
GWJ69_RS20050 4046282..4047733 - 1452 WP_004213726.1 PLP-dependent aminotransferase family protein -
GWJ69_RS20055 4047834..4048532 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
GWJ69_RS20060 4048529..4048669 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GWJ69_RS20065 4048669..4048932 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T289048 WP_002892050.1 NZ_LR745045:4044761-4044979 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT289048 WP_002892066.1 NZ_LR745045:4044360-4044734 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References