289047

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2696943..2698531 Replicon chromosome
Accession NZ_LR745045
Organism Klebsiella pneumoniae isolate Kpn2166

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GWJ69_RS13410 Protein ID WP_004213069.1
Coordinates 2696943..2698265 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GWJ69_RS13415 Protein ID WP_004176198.1
Coordinates 2698265..2698531 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWJ69_RS13395 2691999..2694500 + 2502 WP_004213067.1 fimbrial biogenesis outer membrane usher protein -
GWJ69_RS13400 2694488..2695492 + 1005 WP_004213068.1 type 1 fimbrial protein -
GWJ69_RS13405 2695634..2696926 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
GWJ69_RS13410 2696943..2698265 - 1323 WP_004213069.1 type II toxin-antitoxin system HipA family toxin Toxin
GWJ69_RS13415 2698265..2698531 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
GWJ69_RS13420 2698796..2699122 - 327 WP_004215084.1 hydroxyisourate hydrolase -
GWJ69_RS13425 2699119..2699619 - 501 WP_004215086.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
GWJ69_RS13430 2699597..2700976 - 1380 WP_004215088.1 purine permease -
GWJ69_RS13435 2701322..2702476 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
GWJ69_RS13440 2702457..2703380 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2505800..2733366 227566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.5357

>T289047 WP_004213069.1 NZ_LR745045:c2698265-2696943 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQATGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT289047 WP_004176198.1 NZ_LR745045:c2698531-2698265 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References