Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 798141..798798 Replicon chromosome
Accession NZ_LR745045
Organism Klebsiella pneumoniae isolate Kpn2166

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GWJ69_RS04005 Protein ID WP_002916310.1
Coordinates 798388..798798 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GWJ69_RS04000 Protein ID WP_002916312.1
Coordinates 798141..798407 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWJ69_RS03975 793298..794731 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
GWJ69_RS03980 794850..795578 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GWJ69_RS03985 795627..795938 + 312 WP_162484367.1 N(4)-acetylcytidine aminohydrolase -
GWJ69_RS03990 796102..796761 + 660 WP_002916317.1 hemolysin III family protein -
GWJ69_RS03995 796912..797895 - 984 WP_022615657.1 tRNA-modifying protein YgfZ -
GWJ69_RS04000 798141..798407 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GWJ69_RS04005 798388..798798 + 411 WP_002916310.1 protein YgfX Toxin
GWJ69_RS04010 798805..799326 - 522 WP_002916308.1 flavodoxin FldB -
GWJ69_RS04015 799427..800323 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GWJ69_RS04020 800346..801059 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GWJ69_RS04025 801065..802798 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T289041 WP_002916310.1 NZ_LR745045:798388-798798 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT289041 WP_002916312.1 NZ_LR745045:798141-798407 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References