289039

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 106622..107358 Replicon plasmid pVIR_Kpn154
Accession NZ_LR745043
Organism Klebsiella pneumoniae isolate Klebsiella pneumoniae kpn154

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag GW691_RS26310 Protein ID WP_004098919.1
Coordinates 106622..107104 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7D3T1D0
Locus tag GW691_RS26315 Protein ID WP_004213599.1
Coordinates 107092..107358 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW691_RS26290 101976..103322 + 1347 WP_011154555.1 dihydroorotase -
GW691_RS26295 103386..104408 + 1023 WP_004214536.1 porphobilinogen synthase -
GW691_RS26300 104583..104978 + 396 Protein_115 DDE-type integrase/transposase/recombinase -
GW691_RS26305 104974..106201 - 1228 Protein_116 IS3 family transposase -
GW691_RS26310 106622..107104 - 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
GW691_RS26315 107092..107358 - 267 WP_004213599.1 DUF1778 domain-containing protein Antitoxin
GW691_RS26320 107554..107784 - 231 WP_004213598.1 hypothetical protein -
GW691_RS26325 107798..108001 - 204 WP_004213596.1 hemolysin expression modulator Hha -
GW691_RS26330 108062..108556 - 495 WP_004213594.1 hypothetical protein -
GW691_RS26335 108598..111567 - 2970 WP_004213592.1 Tn3 family transposase -
GW691_RS26340 111570..112127 - 558 WP_004213590.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA2 / rmpA / iutA / iucD / iucC / iucB / iucA / rmpA / iroN / iroD / iroC / iroB 1..215306 215306
- inside IScluster/Tn - - 104974..112127 7153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T289039 WP_004098919.1 NZ_LR745043:c107104-106622 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10151.58 Da        Isoelectric Point: 4.5141

>AT289039 WP_004213599.1 NZ_LR745043:c107358-107092 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRVLIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A7D3T1D0

References