289036

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5167163..5167788 Replicon chromosome
Accession NZ_LR745042
Organism Klebsiella pneumoniae isolate Klebsiella pneumoniae kpn154

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag GW691_RS25340 Protein ID WP_002882817.1
Coordinates 5167163..5167546 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag GW691_RS25345 Protein ID WP_004150355.1
Coordinates 5167546..5167788 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW691_RS25325 5164529..5165431 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
GW691_RS25330 5165428..5166063 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
GW691_RS25335 5166060..5166989 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
GW691_RS25340 5167163..5167546 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
GW691_RS25345 5167546..5167788 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
GW691_RS25350 5167993..5168910 + 918 WP_004213381.1 alpha/beta hydrolase -
GW691_RS25355 5168925..5169866 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
GW691_RS25360 5169911..5170348 - 438 WP_023302745.1 D-tyrosyl-tRNA(Tyr) deacylase -
GW691_RS25365 5170345..5171205 - 861 WP_004146232.1 virulence factor BrkB family protein -
GW691_RS25370 5171199..5171798 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T289036 WP_002882817.1 NZ_LR745042:c5167546-5167163 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT289036 WP_004150355.1 NZ_LR745042:c5167788-5167546 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References