Detailed information of TA system TA289033

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 4627321..4628658
• Replicon: chromosome
• Accession: NZ_LR745042
• Organism: Klebsiella pneumoniae isolate Klebsiella pneumoniae kpn154

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: GW691_RS22760
• Protein ID: WP_032424556.1
• Coordinates: 4627723..4628658 (+)
• Length: 312 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: GW691_RS22755
• Protein ID: WP_023302769.1
• Coordinates: 4627321..4627716 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GW691_RS22725	4622565..4622855	+	291	WP_022615704.1	hypothetical protein	-
GW691_RS22730	4622920..4623825	+	906	WP_022615703.1	DUF1738 domain-containing protein	-
GW691_RS22735	4624018..4624389	+	372	WP_022615702.1	hypothetical protein	-
GW691_RS22740	4624563..4626158	+	1596	WP_023302771.1	TraI domain-containing protein	-
GW691_RS22745	4626330..4626794	+	465	WP_022615700.1	GNAT family N-acetyltransferase	-
GW691_RS22750	4626800..4627066	-	267	WP_023302770.1	hypothetical protein	-
GW691_RS22755	4627321..4627716	+	396	WP_023302769.1	hypothetical protein	Antitoxin
GW691_RS22760	4627723..4628658	+	936	WP_032424556.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
GW691_RS22765	4628666..4629355	-	690	WP_023302767.1	hypothetical protein	-
GW691_RS22770	4629575..4630369	-	795	WP_023302766.1	RES domain-containing protein	-
GW691_RS22775	4630788..4632467	-	1680	WP_004212561.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-298)

Antitoxin

• Protein of unknown function DUF6088 (7-109)

Sequences

Toxin

Protein

• Length: 312 a.a.
• Molecular weight: 35389.66 Da
• Isoelectric Point: 5.6165

>T289033 WP_032424556.1 NZ_LR745042:4627723-4628658 [Klebsiella pneumoniae]
MLFSDVTDALGIESGAIVEKDHYIVELLHLLKPLTFDTHQLLFAGGTALAKSGIVLNRMSEDVDIKLVPTDTFLSLSRTQ
RKGIRKEIVQTISHAITATDMFSFDDAHPKVTRDEYRYNDIPVRYPQRVAQAPCLRPFIQLELMEANLLEAPEFRDIHTL
VTTLTGKAPVISAFPCATIISTQAEKLVAMLRRTAAVARNIERQDDASLVRHIYDTYCIVQAGNVDMCLLTDFFKQTIEQ
DIQRYGNQYPQFCVSPNDELKMGLDELEHNPLYKTRYQQFVAPMVYGARKVSWDEAYASFRQMALIILDTY

Nucleotide

• Length: 936 bp

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14800.08 Da
• Isoelectric Point: 11.1078

>AT289033 WP_023302769.1 NZ_LR745042:4627321-4627716 [Klebsiella pneumoniae]
MTIKTRIQSRLKRSKRYVFTRDDFKDIAGYDQIGRVLRDLLKEGQLLKVGYGVYTKARRNSITGKVMPAAPRGSSAVIVE
TLERLKVRYRYEGATQTYNSGESTQIPVSPEIKTSPRFKRALSVGNSKLNG

Nucleotide

• Length: 396 bp