Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2351848..2352377 Replicon chromosome
Accession NC_020245
Organism Mycobacterium bovis BCG str. Korea 1168P

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag K60_RS10960 Protein ID WP_003411124.1
Coordinates 2351848..2352165 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag K60_RS10965 Protein ID WP_003411127.1
Coordinates 2352162..2352377 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K60_RS10930 2346985..2348061 + 1077 WP_003411110.1 hypothetical protein -
K60_RS10935 2348058..2348339 + 282 WP_019283661.1 hypothetical protein -
K60_RS10940 2348375..2349448 + 1074 WP_011799246.1 quinone-dependent dihydroorotate dehydrogenase -
K60_RS10945 2349453..2349983 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
K60_RS10950 2350031..2351377 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
K60_RS10960 2351848..2352165 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K60_RS10965 2352162..2352377 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
K60_RS10970 2352632..2353690 + 1059 WP_003411129.1 hypothetical protein -
K60_RS10975 2353820..2354176 - 357 WP_003411130.1 hypothetical protein -
K60_RS10980 2354271..2355053 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
K60_RS10985 2355321..2355611 - 291 WP_003900476.1 YggT family protein -
K60_RS10990 2355773..2356429 - 657 WP_003411133.1 cell division protein SepF -
K60_RS10995 2356495..2357271 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T28903 WP_003411124.1 NC_020245:c2352165-2351848 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T28903 NC_020245:c2352165-2351848 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
ATGACGCGTAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT28903 WP_003411127.1 NC_020245:c2352377-2352162 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT28903 NC_020245:c2352377-2352162 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References