289025

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1789263..1789853 Replicon chromosome
Accession NZ_LR745042
Organism Klebsiella pneumoniae isolate Klebsiella pneumoniae kpn154

Toxin (Protein)


Gene name pemK Uniprot ID A0A2L1BXX2
Locus tag GW691_RS08720 Protein ID WP_022615588.1
Coordinates 1789521..1789853 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3S7DDD0
Locus tag GW691_RS08715 Protein ID WP_000288812.1
Coordinates 1789263..1789520 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW691_RS08695 1785599..1787347 + 1749 WP_131312253.1 hypothetical protein -
GW691_RS08700 1787426..1787982 + 557 Protein_1678 hypothetical protein -
GW691_RS08705 1788265..1788725 + 461 Protein_1679 hypothetical protein -
GW691_RS08710 1788722..1788928 + 207 WP_022615589.1 helix-turn-helix domain-containing protein -
GW691_RS08715 1789263..1789520 + 258 WP_000288812.1 antitoxin Antitoxin
GW691_RS08720 1789521..1789853 + 333 WP_022615588.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GW691_RS08735 1790175..1791611 + 1437 WP_004151469.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
GW691_RS08745 1791977..1793431 - 1455 WP_004148975.1 AMP nucleosidase -
GW691_RS08750 1793561..1793806 - 246 WP_004141189.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11913.80 Da        Isoelectric Point: 10.1839

>T289025 WP_022615588.1 NZ_LR745042:1789521-1789853 [Klebsiella pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDVVVNEVLARLDAMLS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9442.92 Da        Isoelectric Point: 4.3566

>AT289025 WP_000288812.1 NZ_LR745042:1789263-1789520 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1BXX2

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DDD0

References