Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 119300..119943 Replicon 1 day old chicken plasmid pAPEC2908
Accession NZ_LR740777
Organism Escherichia coli strain BEN2908 isolate

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag APEC2908_RS25350 Protein ID WP_001034044.1
Coordinates 119527..119943 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag APEC2908_RS25345 Protein ID WP_001261286.1
Coordinates 119300..119530 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC2908_RS25330 114717..117809 - 3093 Protein_115 pcar -
APEC2908_RS25335 117865..118562 + 698 Protein_116 IS1 family transposase -
APEC2908_RS25340 118497..118919 - 423 WP_161476339.1 hypothetical protein -
APEC2908_RS25345 119300..119530 + 231 WP_001261286.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
APEC2908_RS25350 119527..119943 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
APEC2908_RS25355 120018..121583 + 1566 WP_001128474.1 AAA family ATPase -
APEC2908_RS25360 121568..122590 + 1023 WP_000361402.1 helicase UvrD -
APEC2908_RS25365 122844..123540 - 697 Protein_122 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sitABCD iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA 1..152011 152011
- inside IScluster/Tn - - 118059..123089 5030


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T289022 WP_001034044.1 NZ_LR740777:119527-119943 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT289022 WP_001261286.1 NZ_LR740777:119300-119530 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References