Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4658006..4658838 Replicon chromosome
Accession NZ_LR740776
Organism Escherichia coli strain BEN2908 isolate

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag APEC2908_RS22710 Protein ID WP_000854753.1
Coordinates 4658006..4658380 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag APEC2908_RS22715 Protein ID WP_001278232.1
Coordinates 4658470..4658838 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC2908_RS22690 4654359..4655897 - 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -
APEC2908_RS22695 4656646..4657215 - 570 WP_001290247.1 DUF4942 domain-containing protein -
APEC2908_RS22700 4657312..4657509 - 198 WP_000839281.1 DUF957 domain-containing protein -
APEC2908_RS22705 4657521..4658009 - 489 WP_000777541.1 hypothetical protein -
APEC2908_RS22710 4658006..4658380 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
APEC2908_RS22715 4658470..4658838 - 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
APEC2908_RS22720 4659001..4659222 - 222 WP_000692303.1 DUF987 domain-containing protein -
APEC2908_RS22725 4659285..4659758 - 474 WP_161476291.1 RadC family protein -
APEC2908_RS22730 4659768..4660246 - 479 Protein_4435 antirestriction protein -
APEC2908_RS22735 4660328..4661146 - 819 WP_001234631.1 DUF945 domain-containing protein -
APEC2908_RS22740 4661244..4661476 - 233 Protein_4437 DUF905 family protein -
APEC2908_RS22745 4661482..4662159 - 678 WP_001097305.1 hypothetical protein -
APEC2908_RS22750 4662307..4662987 - 681 WP_001593697.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T289011 WP_000854753.1 NZ_LR740776:c4658380-4658006 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT289011 WP_001278232.1 NZ_LR740776:c4658838-4658470 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References