Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4049398..4050263 Replicon chromosome
Accession NZ_LR740776
Organism Escherichia coli strain BEN2908 isolate

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag APEC2908_RS19835 Protein ID WP_174235614.1
Coordinates 4049856..4050263 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q5I3J0
Locus tag APEC2908_RS19830 Protein ID WP_001280951.1
Coordinates 4049398..4049766 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC2908_RS19800 4046233..4046657 + 425 Protein_3875 hypothetical protein -
APEC2908_RS19805 4046763..4046995 + 233 Protein_3876 DUF905 family protein -
APEC2908_RS19810 4047095..4047913 + 819 WP_001234620.1 DUF945 domain-containing protein -
APEC2908_RS19815 4047968..4048453 + 486 WP_161476275.1 antirestriction protein -
APEC2908_RS19820 4048469..4048945 + 477 WP_001186724.1 RadC family protein -
APEC2908_RS19825 4049014..4049235 + 222 WP_001405861.1 DUF987 domain-containing protein -
APEC2908_RS19830 4049398..4049766 + 369 WP_001280951.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
APEC2908_RS19835 4049856..4050263 + 408 WP_174235614.1 TA system toxin CbtA family protein Toxin
APEC2908_RS19840 4050226..4050714 + 489 WP_001549830.1 hypothetical protein -
APEC2908_RS19845 4050726..4050923 + 198 WP_000839243.1 DUF957 domain-containing protein -
APEC2908_RS19850 4051008..4051853 + 846 WP_097416764.1 DUF4942 domain-containing protein -
APEC2908_RS19855 4052446..4052944 + 499 Protein_3886 hypothetical protein -
APEC2908_RS19860 4053111..4054034 + 924 WP_001351210.1 carboxylate/amino acid/amine transporter -
APEC2908_RS19865 4054038..4054856 - 819 WP_000779409.1 lipoprotein NlpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4037480..4052814 15334


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15204.16 Da        Isoelectric Point: 7.2150

>T289008 WP_174235614.1 NZ_LR740776:4049856-4050263 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITTVSIRRNDETFPDAGSRQN

Download         Length: 408 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13699.56 Da        Isoelectric Point: 7.0268

>AT289008 WP_001280951.1 NZ_LR740776:4049398-4049766 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q5I3J0

References