288982

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 142845..143370 Replicon plasmid paAPEC5202
Accession NZ_LR740759
Organism Escherichia coli strain BEN5202 isolate laying hen 51 weeks old

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag APEC5202_RS25580 Protein ID WP_001159871.1
Coordinates 143065..143370 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag APEC5202_RS25575 Protein ID WP_000813630.1
Coordinates 142845..143063 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC5202_RS25545 138239..138655 - 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
APEC5202_RS25550 138652..138882 - 231 WP_001261278.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
APEC5202_RS25555 139147..139647 + 501 WP_000528932.1 hypothetical protein -
APEC5202_RS25560 139660..140433 + 774 WP_000905949.1 hypothetical protein -
APEC5202_RS25565 140600..141733 + 1134 WP_000545987.1 DUF3800 domain-containing protein -
APEC5202_RS25570 141767..142279 - 513 WP_000151784.1 hypothetical protein -
APEC5202_RS25575 142845..143063 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
APEC5202_RS25580 143065..143370 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
APEC5202_RS25585 143371..144177 + 807 WP_000016968.1 site-specific integrase -
APEC5202_RS25590 144857..145588 - 732 WP_000504262.1 replication initiation protein -
APEC5202_RS25595 146209..147414 + 1206 WP_001442122.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(B) / sitABCD vat / iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA 1..223939 223939


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T288982 WP_001159871.1 NZ_LR740759:143065-143370 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8354.27 Da        Isoelectric Point: 4.5203

>AT288982 WP_000813630.1 NZ_LR740759:142845-143063 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTLQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References