Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 138239..138882 | Replicon | plasmid paAPEC5202 |
Accession | NZ_LR740759 | ||
Organism | Escherichia coli strain BEN5202 isolate laying hen 51 weeks old |
Toxin (Protein)
Gene name | vagD | Uniprot ID | C7S9Y5 |
Locus tag | APEC5202_RS25545 | Protein ID | WP_001034046.1 |
Coordinates | 138239..138655 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | V0SR71 |
Locus tag | APEC5202_RS25550 | Protein ID | WP_001261278.1 |
Coordinates | 138652..138882 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
APEC5202_RS25530 | 133376..133792 | - | 417 | WP_001034044.1 | type II toxin-antitoxin system VapC family toxin | - |
APEC5202_RS25535 | 133789..134019 | - | 231 | WP_001261286.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
APEC5202_RS25540 | 134400..138194 | + | 3795 | WP_001144732.1 | hypothetical protein | - |
APEC5202_RS25545 | 138239..138655 | - | 417 | WP_001034046.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
APEC5202_RS25550 | 138652..138882 | - | 231 | WP_001261278.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
APEC5202_RS25555 | 139147..139647 | + | 501 | WP_000528932.1 | hypothetical protein | - |
APEC5202_RS25560 | 139660..140433 | + | 774 | WP_000905949.1 | hypothetical protein | - |
APEC5202_RS25565 | 140600..141733 | + | 1134 | WP_000545987.1 | DUF3800 domain-containing protein | - |
APEC5202_RS25570 | 141767..142279 | - | 513 | WP_000151784.1 | hypothetical protein | - |
APEC5202_RS25575 | 142845..143063 | + | 219 | WP_000813630.1 | type II toxin-antitoxin system antitoxin CcdA | - |
APEC5202_RS25580 | 143065..143370 | + | 306 | WP_001159871.1 | type II toxin-antitoxin system toxin CcdB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | tet(B) / sitABCD | vat / iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA | 1..223939 | 223939 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 14978.31 Da Isoelectric Point: 6.7113
>T288981 WP_001034046.1 NZ_LR740759:c138655-138239 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIATGAILVTNNVREFERVPGLVLEDWAG
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIATGAILVTNNVREFERVPGLVLEDWAG
Download Length: 417 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9NXF9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V0SR71 |