288973

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4766259..4766756 Replicon chromosome
Accession NZ_LR740758
Organism Escherichia coli strain BEN5202 isolate laying hen 51 weeks old

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag APEC5202_RS23150 Protein ID WP_001173343.1
Coordinates 4766583..4766756 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag APEC5202_RS23145 Protein ID WP_001312331.1
Coordinates 4766259..4766555 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC5202_RS23125 4762989..4763708 - 720 WP_000611291.1 two-component system response regulator DcuR -
APEC5202_RS23130 4763705..4765336 - 1632 WP_001216482.1 sensor histidine kinase -
APEC5202_RS23135 4765517..4765747 + 231 WP_000373293.1 (4Fe-4S)-binding protein -
APEC5202_RS23140 4765759..4766031 + 273 WP_000405647.1 N-acetyltransferase -
APEC5202_RS23145 4766259..4766555 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
APEC5202_RS23150 4766583..4766756 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
APEC5202_RS23155 4766875..4768392 - 1518 WP_000003806.1 lysine--tRNA ligase -
APEC5202_RS23160 4768629..4770086 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T288973 WP_001173343.1 NZ_LR740758:4766583-4766756 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT288973 WP_001312331.1 NZ_LR740758:4766259-4766555 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References