288972

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4606372..4607360 Replicon chromosome
Accession NZ_LR740758
Organism Escherichia coli strain BEN5202 isolate laying hen 51 weeks old

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag APEC5202_RS26625 Protein ID WP_014640052.1
Coordinates 4606974..4607360 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0A1AFM1
Locus tag APEC5202_RS22345 Protein ID WP_000458583.1
Coordinates 4606372..4606944 (+) Length 191 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC5202_RS22320 4602534..4602902 + 369 WP_000002899.1 diacylglycerol kinase -
APEC5202_RS22325 4603012..4603620 + 609 WP_000646078.1 transcriptional repressor LexA -
APEC5202_RS22330 4603693..4605018 + 1326 WP_001296637.1 MATE family efflux transporter DinF -
APEC5202_RS22335 4605134..4605343 + 210 WP_001296638.1 CsbD family protein -
APEC5202_RS22340 4605385..4605900 - 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
APEC5202_RS22345 4606372..4606944 + 573 WP_000458583.1 SocA family protein Antitoxin
APEC5202_RS26625 4606974..4607360 + 387 WP_014640052.1 hypothetical protein Toxin
APEC5202_RS26770 4607400..4607573 + 174 WP_000390072.1 hypothetical protein -
APEC5202_RS22350 4607621..4607902 - 282 WP_001093916.1 pyocin activator PrtN family protein -
APEC5202_RS22355 4607939..4608511 - 573 WP_001061345.1 3'-5' exoribonuclease -
APEC5202_RS22360 4608511..4609269 - 759 WP_021518219.1 DUF551 domain-containing protein -
APEC5202_RS22365 4609272..4609463 - 192 WP_001014291.1 hypothetical protein -
APEC5202_RS22370 4609465..4610019 - 555 WP_021518220.1 ead/Ea22-like family protein -
APEC5202_RS22375 4610016..4610255 - 240 WP_000476212.1 hypothetical protein -
APEC5202_RS22380 4610248..4610451 - 204 WP_021518221.1 hypothetical protein -
APEC5202_RS22385 4610448..4611326 - 879 WP_021518222.1 phosphoadenosine phosphosulfate reductase family protein -
APEC5202_RS22390 4611317..4611853 - 537 WP_021518223.1 5'-deoxynucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4603012..4664622 61610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-137)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T288972 WP_014640052.1 NZ_LR740758:4606974-4607360 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21956.30 Da        Isoelectric Point: 6.0283

>AT288972 WP_000458583.1 NZ_LR740758:4606372-4606944 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AFM1

References