288964

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3160515..3161169 Replicon chromosome
Accession NZ_LR740758
Organism Escherichia coli strain BEN5202 isolate laying hen 51 weeks old

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag APEC5202_RS15445 Protein ID WP_000244781.1
Coordinates 3160515..3160922 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag APEC5202_RS15450 Protein ID WP_000354046.1
Coordinates 3160903..3161169 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC5202_RS15425 3156472..3158205 - 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -
APEC5202_RS15430 3158211..3158921 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
APEC5202_RS15435 3158946..3159842 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
APEC5202_RS15440 3159954..3160475 + 522 WP_001055874.1 flavodoxin FldB -
APEC5202_RS15445 3160515..3160922 - 408 WP_000244781.1 protein YgfX Toxin
APEC5202_RS15450 3160903..3161169 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
APEC5202_RS15455 3161412..3162392 + 981 WP_000886078.1 tRNA-modifying protein YgfZ -
APEC5202_RS15460 3162469..3163128 - 660 WP_000250274.1 hemolysin III family protein -
APEC5202_RS15465 3163292..3163603 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
APEC5202_RS15470 3163648..3165081 + 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T288964 WP_000244781.1 NZ_LR740758:c3160922-3160515 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT288964 WP_000354046.1 NZ_LR740758:c3161169-3160903 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References