Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2175486..2176030 | Replicon | chromosome |
| Accession | NC_020245 | ||
| Organism | Mycobacterium bovis BCG str. Korea 1168P | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | K60_RS10095 | Protein ID | WP_003409896.1 |
| Coordinates | 2175486..2175782 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | K60_RS10100 | Protein ID | WP_003409899.1 |
| Coordinates | 2175779..2176030 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K60_RS10040 | 2170519..2170869 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| K60_RS10045 | 2170880..2171782 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| K60_RS10050 | 2171803..2171994 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| K60_RS10055 | 2171995..2172291 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| K60_RS10060 | 2172531..2172746 | + | 216 | WP_003409878.1 | antitoxin | - |
| K60_RS10065 | 2172743..2173054 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| K60_RS22300 | 2173028..2173549 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| K60_RS10075 | 2173524..2173901 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| K60_RS10080 | 2173943..2174392 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| K60_RS10085 | 2174389..2174934 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| K60_RS10090 | 2174823..2175437 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| K60_RS10095 | 2175486..2175782 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K60_RS10100 | 2175779..2176030 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| K60_RS10105 | 2176017..2176511 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| K60_RS10110 | 2176671..2177078 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| K60_RS10115 | 2177082..2177354 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| K60_RS10120 | 2177387..2178607 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| K60_RS10130 | 2179506..2179811 | + | 306 | Protein_1978 | ABC transporter permease | - |
| K60_RS10135 | 2179995..2180519 | + | 525 | WP_011799234.1 | methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T28896 WP_003409896.1 NC_020245:c2175782-2175486 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T28896 NC_020245:c2175782-2175486 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT28896 WP_003409899.1 NC_020245:c2176030-2175779 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT28896 NC_020245:c2176030-2175779 [Mycobacterium tuberculosis variant bovis BCG str. Korea 1168P]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |