Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1648065..1649653 Replicon chromosome
Accession NZ_LR740758
Organism Escherichia coli strain BEN5202 isolate laying hen 51 weeks old

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag APEC5202_RS08045 Protein ID WP_001125475.1
Coordinates 1648331..1649653 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag APEC5202_RS08040 Protein ID WP_001332145.1
Coordinates 1648065..1648331 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC5202_RS08025 1644433..1645884 + 1452 WP_001513806.1 tagaturonate reductase -
APEC5202_RS08030 1646081..1646995 + 915 WP_001306069.1 bestrophin family protein -
APEC5202_RS08035 1646999..1647757 - 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
APEC5202_RS08040 1648065..1648331 + 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
APEC5202_RS08045 1648331..1649653 + 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
APEC5202_RS08050 1649911..1650168 - 258 WP_001210030.1 hypothetical protein -
APEC5202_RS08055 1650278..1651060 + 783 WP_001221834.1 SDR family oxidoreductase -
APEC5202_RS08060 1651543..1652106 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
APEC5202_RS08065 1652468..1653178 + 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T288959 WP_001125475.1 NZ_LR740758:1648331-1649653 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT288959 WP_001332145.1 NZ_LR740758:1648065-1648331 [Escherichia coli]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References