Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4584458..4585716 Replicon chromosome
Accession NZ_LR739071
Organism Pseudomonas aeruginosa strain C7-25 isolate C7-25

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PERCYII40_RS21135 Protein ID WP_003123189.1
Coordinates 4584458..4585213 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PERCYII40_RS21140 Protein ID WP_003086329.1
Coordinates 4585348..4585716 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PERCYII40_RS21125 4579631..4582174 + 2544 WP_003123188.1 acyl-homoserine-lactone acylase QuiP -
PERCYII40_RS21130 4582329..4583690 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PERCYII40_RS21135 4584458..4585213 - 756 WP_003123189.1 RES family NAD+ phosphorylase Toxin
PERCYII40_RS21140 4585348..4585716 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PERCYII40_RS21145 4585789..4587075 - 1287 WP_003123190.1 FAD-binding oxidoreductase -
PERCYII40_RS21150 4587131..4588720 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PERCYII40_RS21155 4588799..4589275 + 477 WP_003112531.1 hypothetical protein -
PERCYII40_RS29995 4589278..4589553 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28267.46 Da        Isoelectric Point: 8.3428

>T288947 WP_003123189.1 NZ_LR739071:c4585213-4584458 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQKLGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT288947 WP_003086329.1 NZ_LR739071:c4585716-4585348 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References