288946

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3577173..3578394 Replicon chromosome
Accession NZ_LR739071
Organism Pseudomonas aeruginosa strain C7-25 isolate C7-25

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PERCYII40_RS16415 Protein ID WP_003102740.1
Coordinates 3577816..3578394 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PERCYII40_RS16410 Protein ID WP_049304404.1
Coordinates 3577173..3577727 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PERCYII40_RS16385 3572741..3573292 + 552 WP_003102727.1 XRE family transcriptional regulator -
PERCYII40_RS16390 3573289..3573687 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PERCYII40_RS16395 3573700..3574023 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PERCYII40_RS16400 3574354..3574815 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PERCYII40_RS16405 3574820..3577015 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PERCYII40_RS16410 3577173..3577727 + 555 WP_049304404.1 helix-turn-helix domain-containing protein Antitoxin
PERCYII40_RS16415 3577816..3578394 + 579 WP_003102740.1 HD domain-containing protein Toxin
PERCYII40_RS16420 3578503..3579690 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PERCYII40_RS16425 3579680..3581851 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
PERCYII40_RS16430 3581841..3583118 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T288946 WP_003102740.1 NZ_LR739071:3577816-3578394 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20484.66 Da        Isoelectric Point: 8.1590

>AT288946 WP_049304404.1 NZ_LR739071:3577173-3577727 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLTPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References