Detailed information of TA system TA288945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1895099..1896607
• Replicon: chromosome
• Accession: NZ_LR739071
• Organism: Pseudomonas aeruginosa strain C7-25 isolate C7-25

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PERCYII40_RS08860
• Protein ID: WP_012613851.1
• Coordinates: 1895099..1895686 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PERCYII40_RS08865
• Protein ID: WP_012613852.1
• Coordinates: 1895753..1896607 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PERCYII40_RS08855	1891354..1894833	-	3480	WP_023115144.1	hybrid sensor histidine kinase/response regulator	-
PERCYII40_RS08860	1895099..1895686	+	588	WP_012613851.1	GNAT family N-acetyltransferase	Toxin
PERCYII40_RS08865	1895753..1896607	+	855	WP_012613852.1	AraC family transcriptional regulator	Antitoxin
PERCYII40_RS08870	1896704..1898869	+	2166	WP_003091606.1	TonB-dependent receptor family protein	-
PERCYII40_RS08875	1899044..1900918	+	1875	WP_023128709.1	MFS transporter	-
PERCYII40_RS08880	1900979..1901188	-	210	WP_003091604.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21929.29 Da
• Isoelectric Point: 9.8676

>T288945 WP_012613851.1 NZ_LR739071:1895099-1895686 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Nucleotide

• Length: 588 bp

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31959.27 Da
• Isoelectric Point: 7.3276

>AT288945 WP_012613852.1 NZ_LR739071:1895753-1896607 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Nucleotide

• Length: 855 bp