Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1625230..1626925 | Replicon | chromosome |
| Accession | NZ_LR739071 | ||
| Organism | Pseudomonas aeruginosa strain C7-25 isolate C7-25 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9HYA0 |
| Locus tag | PERCYII40_RS07605 | Protein ID | WP_003112901.1 |
| Coordinates | 1625230..1626099 (+) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q9HYA1 |
| Locus tag | PERCYII40_RS07610 | Protein ID | WP_003112902.1 |
| Coordinates | 1626092..1626925 (+) | Length | 278 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PERCYII40_RS07580 | 1621238..1622089 | + | 852 | WP_003130104.1 | ABC transporter ATP-binding protein | - |
| PERCYII40_RS07585 | 1622130..1623137 | + | 1008 | WP_003112897.1 | ABC transporter substrate-binding protein | - |
| PERCYII40_RS07590 | 1623134..1623910 | + | 777 | WP_003112898.1 | ABC transporter permease | - |
| PERCYII40_RS07595 | 1623916..1624677 | + | 762 | WP_003112899.1 | SDR family oxidoreductase | - |
| PERCYII40_RS07600 | 1624691..1625221 | + | 531 | WP_003112900.1 | cupin domain-containing protein | - |
| PERCYII40_RS07605 | 1625230..1626099 | + | 870 | WP_003112901.1 | alpha/beta hydrolase | Toxin |
| PERCYII40_RS07610 | 1626092..1626925 | + | 834 | WP_003112902.1 | IclR family transcriptional regulator | Antitoxin |
| PERCYII40_RS07615 | 1626912..1627709 | + | 798 | WP_003112903.1 | SDR family oxidoreductase | - |
| PERCYII40_RS07620 | 1627702..1629384 | + | 1683 | WP_003130114.1 | thiamine pyrophosphate-binding protein | - |
| PERCYII40_RS07625 | 1629395..1630198 | + | 804 | WP_003130116.1 | aspartate dehydrogenase | - |
| PERCYII40_RS07630 | 1630210..1631694 | + | 1485 | WP_128654386.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30403.60 Da Isoelectric Point: 6.5894
>T288944 WP_003112901.1 NZ_LR739071:1625230-1626099 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
Download Length: 870 bp
Antitoxin
Download Length: 278 a.a. Molecular weight: 30877.26 Da Isoelectric Point: 5.7725
>AT288944 WP_003112902.1 NZ_LR739071:1626092-1626925 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
Download Length: 834 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|