Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 652423..653060 Replicon chromosome
Accession NZ_LR739071
Organism Pseudomonas aeruginosa strain C7-25 isolate C7-25

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PERCYII40_RS03045 Protein ID WP_019725766.1
Coordinates 652423..652605 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PERCYII40_RS03050 Protein ID WP_019725767.1
Coordinates 652638..653060 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PERCYII40_RS03035 648995..649549 - 555 WP_049955763.1 hypothetical protein -
PERCYII40_RS03040 650772..651845 - 1074 WP_003121829.1 site-specific integrase -
PERCYII40_RS03045 652423..652605 + 183 WP_019725766.1 type II toxin-antitoxin system HicA family toxin Toxin
PERCYII40_RS03050 652638..653060 + 423 WP_019725767.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PERCYII40_RS03055 653306..654277 - 972 WP_033946036.1 hypothetical protein -
PERCYII40_RS03060 654262..654954 - 693 WP_033946051.1 hypothetical protein -
PERCYII40_RS03065 654951..655493 - 543 WP_025982284.1 hypothetical protein -
PERCYII40_RS03070 655490..656413 - 924 WP_033946052.1 hypothetical protein -
PERCYII40_RS03075 656410..656886 - 477 WP_033946054.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 625576..682659 57083


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6970.07 Da        Isoelectric Point: 10.2954

>T288943 WP_019725766.1 NZ_LR739071:652423-652605 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Download         Length: 183 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 14970.22 Da        Isoelectric Point: 4.9047

>AT288943 WP_019725767.1 NZ_LR739071:652638-653060 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References