Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4863716..4864974 Replicon chromosome
Accession NZ_LR739069
Organism Pseudomonas aeruginosa strain PcyII-40 isolate PcyII-40

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag G3R43_RS22815 Protein ID WP_003086331.1
Coordinates 4863716..4864471 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag G3R43_RS22820 Protein ID WP_003086329.1
Coordinates 4864606..4864974 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3R43_RS22805 4858887..4861430 + 2544 WP_003108653.1 acyl-homoserine-lactone acylase QuiP -
G3R43_RS22810 4861585..4862946 - 1362 WP_003081943.1 DNA recombination protein RmuC -
G3R43_RS22815 4863716..4864471 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
G3R43_RS22820 4864606..4864974 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
G3R43_RS22825 4865047..4866333 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
G3R43_RS22830 4866389..4867978 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
G3R43_RS22835 4868057..4868533 + 477 WP_004353334.1 elongation factor GreAB -
G3R43_RS32195 4868536..4868796 - 261 WP_023095977.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T288940 WP_003086331.1 NZ_LR739069:c4864471-4863716 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT288940 WP_003086329.1 NZ_LR739069:c4864974-4864606 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References