Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3874226..3875446 Replicon chromosome
Accession NZ_LR739069
Organism Pseudomonas aeruginosa strain PcyII-40 isolate PcyII-40

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag G3R43_RS18090 Protein ID WP_003110488.1
Coordinates 3874868..3875446 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G3R43_RS18085 Protein ID WP_003088112.1
Coordinates 3874226..3874780 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3R43_RS18060 3869794..3870345 + 552 WP_003132721.1 XRE family transcriptional regulator -
G3R43_RS18065 3870342..3870740 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
G3R43_RS18070 3870753..3871076 - 324 WP_003102734.1 multidrug efflux SMR transporter -
G3R43_RS18075 3871407..3871868 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
G3R43_RS18080 3871873..3874068 + 2196 WP_114220376.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
G3R43_RS18085 3874226..3874780 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
G3R43_RS18090 3874868..3875446 + 579 WP_003110488.1 HD domain-containing protein Toxin
G3R43_RS18095 3875556..3876743 - 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
G3R43_RS18100 3876733..3878904 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
G3R43_RS18105 3878894..3880171 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T288939 WP_003110488.1 NZ_LR739069:3874868-3875446 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT288939 WP_003088112.1 NZ_LR739069:3874226-3874780 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References