Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4582190..4583448 Replicon chromosome
Accession NZ_LR739068
Organism Pseudomonas aeruginosa strain PcyII-29 isolate PcyII-29

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag G3R42_RS21220 Protein ID WP_003112528.1
Coordinates 4582190..4582945 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag G3R42_RS21225 Protein ID WP_003086329.1
Coordinates 4583080..4583448 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3R42_RS21210 4577363..4579906 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
G3R42_RS21215 4580061..4581422 - 1362 WP_073647918.1 DNA recombination protein RmuC -
G3R42_RS21220 4582190..4582945 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
G3R42_RS21225 4583080..4583448 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
G3R42_RS21230 4583521..4584807 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
G3R42_RS21235 4584863..4586452 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
G3R42_RS21240 4586531..4587007 + 477 WP_003112531.1 hypothetical protein -
G3R42_RS30840 4587010..4587285 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T288932 WP_003112528.1 NZ_LR739068:c4582945-4582190 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT288932 WP_003086329.1 NZ_LR739068:c4583448-4583080 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References