Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3669341..3670562 Replicon chromosome
Accession NZ_LR739068
Organism Pseudomonas aeruginosa strain PcyII-29 isolate PcyII-29

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag G3R42_RS16925 Protein ID WP_003102740.1
Coordinates 3669984..3670562 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G3R42_RS16920 Protein ID WP_003088112.1
Coordinates 3669341..3669895 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3R42_RS16895 3664909..3665460 + 552 WP_003102727.1 XRE family transcriptional regulator -
G3R42_RS16900 3665457..3665855 - 399 WP_003102731.1 NADH-quinone oxidoreductase subunit A -
G3R42_RS16905 3665868..3666191 - 324 WP_003102734.1 multidrug efflux SMR transporter -
G3R42_RS16910 3666522..3666983 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
G3R42_RS16915 3666988..3669183 + 2196 WP_003102738.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
G3R42_RS16920 3669341..3669895 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
G3R42_RS16925 3669984..3670562 + 579 WP_003102740.1 HD domain-containing protein Toxin
G3R42_RS16930 3670672..3671859 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
G3R42_RS16935 3671849..3674020 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
G3R42_RS16940 3674010..3675287 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T288931 WP_003102740.1 NZ_LR739068:3669984-3670562 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT288931 WP_003088112.1 NZ_LR739068:3669341-3669895 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References