Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1038701..1039196 Replicon chromosome
Accession NZ_LR738724
Organism Streptococcus suis isolate 9401240

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GPW69_RS05170 Protein ID WP_074391125.1
Coordinates 1038930..1039196 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A123SEG2
Locus tag GPW69_RS05165 Protein ID WP_015646833.1
Coordinates 1038701..1038940 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW69_RS05140 1034029..1035195 + 1167 WP_074391122.1 ATP-grasp domain-containing protein -
GPW69_RS05145 1035336..1035476 + 141 WP_044683303.1 hypothetical protein -
GPW69_RS05150 1035489..1035884 + 396 WP_074391123.1 NisI/SpaI family lantibiotic immunity lipoprotein -
GPW69_RS05155 1035887..1036639 + 753 WP_024407069.1 ABC transporter ATP-binding protein -
GPW69_RS05160 1036640..1038610 + 1971 WP_074391124.1 ABC transporter permease -
GPW69_RS05165 1038701..1038940 + 240 WP_015646833.1 hypothetical protein Antitoxin
GPW69_RS05170 1038930..1039196 + 267 WP_074391125.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW69_RS05175 1039238..1039903 + 666 WP_074391126.1 response regulator transcription factor -
GPW69_RS05180 1039900..1040841 + 942 WP_074391127.1 sensor histidine kinase -
GPW69_RS05185 1040916..1042424 + 1509 WP_074391128.1 phosphomannomutase/phosphoglucomutase -
GPW69_RS05190 1042488..1043558 - 1071 WP_074391129.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10287.99 Da        Isoelectric Point: 10.3654

>T288925 WP_074391125.1 NZ_LR738724:1038930-1039196 [Streptococcus suis]
MSYKVILSVKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGQALTANRSGQWRYRIGNYRVIVSIEDDKLIITALEV
GHRKEVYK

Download         Length: 267 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8879.09 Da        Isoelectric Point: 3.7832

>AT288925 WP_015646833.1 NZ_LR738724:1038701-1038940 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A123SEG2

References