Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1008940..1010183 Replicon chromosome
Accession NZ_LR738724
Organism Streptococcus suis isolate 9401240

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag GPW69_RS05025 Protein ID WP_074391115.1
Coordinates 1009416..1010183 (+) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag GPW69_RS05020 Protein ID WP_074391114.1
Coordinates 1008940..1009416 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW69_RS04970 1003978..1004874 + 897 WP_001809760.1 ParA family protein -
GPW69_RS04975 1004972..1005154 + 183 WP_171841452.1 peptide-binding protein -
GPW69_RS04980 1005175..1005339 + 165 WP_074391110.1 helicase SNF2 -
GPW69_RS04985 1005410..1005709 + 300 WP_024401832.1 hypothetical protein -
GPW69_RS04990 1005723..1006013 + 291 WP_074391111.1 hypothetical protein -
GPW69_RS04995 1006109..1006747 + 639 WP_074391112.1 peptidylprolyl isomerase -
GPW69_RS05000 1006787..1007863 + 1077 WP_002943343.1 toprim domain-containing protein -
GPW69_RS05005 1007917..1008144 + 228 WP_002935073.1 hypothetical protein -
GPW69_RS05010 1008141..1008530 + 390 WP_002935071.1 hypothetical protein -
GPW69_RS05015 1008580..1008870 + 291 WP_171841453.1 hypothetical protein -
GPW69_RS05020 1008940..1009416 + 477 WP_074391114.1 helix-turn-helix domain-containing protein Antitoxin
GPW69_RS05025 1009416..1010183 + 768 WP_074391115.1 zeta toxin family protein Toxin
GPW69_RS05030 1010219..1012726 + 2508 WP_002935064.1 AAA family ATPase -
GPW69_RS05035 1013061..1013420 + 360 WP_002935059.1 hypothetical protein -
GPW69_RS05040 1013430..1013795 + 366 WP_018163914.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(O) / erm(B) - 996806..1028749 31943


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29078.90 Da        Isoelectric Point: 5.2522

>T288924 WP_074391115.1 NZ_LR738724:1009416-1010183 [Streptococcus suis]
MRLEEFSEADFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQFLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELEREQLFDQIQIYQRDRTCIYDSAIDEGSAAEVLQECLFGKWSKVEEEMV
KESELLLNELLEKNK

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18287.70 Da        Isoelectric Point: 4.4042

>AT288924 WP_074391114.1 NZ_LR738724:1008940-1009416 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVETFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References