Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 980357..981789 Replicon chromosome
Accession NZ_LR738724
Organism Streptococcus suis isolate 9401240

Toxin (Protein)


Gene name abiEi Uniprot ID A0A346FW44
Locus tag GPW69_RS04880 Protein ID WP_074390955.1
Coordinates 980357..981202 (-) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A6G6AVK6
Locus tag GPW69_RS04885 Protein ID WP_074390956.1
Coordinates 981199..981789 (-) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW69_RS04875 978113..980026 + 1914 WP_074390954.1 group II intron reverse transcriptase/maturase -
GPW69_RS04880 980357..981202 - 846 WP_074390955.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
GPW69_RS04885 981199..981789 - 591 WP_074390956.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32462.14 Da        Isoelectric Point: 5.4360

>T288923 WP_074390955.1 NZ_LR738724:c981202-980357 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLRNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Download         Length: 846 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23279.87 Da        Isoelectric Point: 7.8482

>AT288923 WP_074390956.1 NZ_LR738724:c981789-981199 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAIFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDLERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A346FW44

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6AVK6

References