Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 629487..629973 Replicon chromosome
Accession NZ_LR738724
Organism Streptococcus suis isolate 9401240

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8G620
Locus tag GPW69_RS03260 Protein ID WP_024385504.1
Coordinates 629704..629973 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag GPW69_RS03255 Protein ID WP_002938604.1
Coordinates 629487..629714 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW69_RS03230 624965..625510 - 546 WP_024385507.1 NAD(P)H-dependent oxidoreductase -
GPW69_RS03235 625573..626022 - 450 WP_009909619.1 MarR family transcriptional regulator -
GPW69_RS03240 626235..626732 + 498 WP_044679671.1 DUF5590 domain-containing protein -
GPW69_RS03245 626729..627910 + 1182 WP_024385505.1 pyridoxal phosphate-dependent aminotransferase -
GPW69_RS03250 627925..629271 + 1347 WP_014638198.1 asparagine--tRNA ligase -
GPW69_RS03255 629487..629714 + 228 WP_002938604.1 hypothetical protein Antitoxin
GPW69_RS03260 629704..629973 + 270 WP_024385504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW69_RS03270 630327..631646 + 1320 WP_024412167.1 MATE family efflux transporter -
GPW69_RS03275 631830..632207 + 378 WP_024412168.1 RidA family protein -
GPW69_RS03280 632229..633116 + 888 WP_024412169.1 RNase adapter RapZ -
GPW69_RS03285 633113..634087 + 975 WP_024400159.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10463.52 Da        Isoelectric Point: 10.3192

>T288922 WP_024385504.1 NZ_LR738724:629704-629973 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GYRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT288922 WP_002938604.1 NZ_LR738724:629487-629714 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8G620

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References