Detailed information of TA system TA288921

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 236836..238106
• Replicon: chromosome
• Accession: NZ_LR738724
• Organism: Streptococcus suis isolate 9401240

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: GPW69_RS01300
• Protein ID: WP_074391384.1
• Coordinates: 237312..238106 (+)
• Length: 265 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: GPW69_RS01295
• Protein ID: WP_074391383.1
• Coordinates: 236836..237312 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPW69_RS01275	232594..233439	+	846	WP_024384741.1	aquaporin family protein	-
GPW69_RS01280	233569..235089	+	1521	WP_024406801.1	DUF853 family protein	-
GPW69_RS01285	235201..235815	+	615	WP_044751282.1	CoA pyrophosphatase	-
GPW69_RS01290	235859..236527	-	669	WP_074391382.1	aquaporin	-
GPW69_RS01295	236836..237312	+	477	WP_074391383.1	helix-turn-helix domain-containing protein	Antitoxin
GPW69_RS01300	237312..238106	+	795	WP_074391384.1	zeta toxin family protein	Toxin
GPW69_RS01305	238087..240153	+	2067	WP_074391385.1	ATP-dependent endonuclease	-
GPW69_RS01310	240135..242057	+	1923	WP_074391431.1	ATP-dependent helicase	-
GPW69_RS01315	242077..242667	+	591	WP_074391386.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 265 a.a.
• Molecular weight: 30159.01 Da
• Isoelectric Point: 5.4668

>T288921 WP_074391384.1 NZ_LR738724:237312-238106 [Streptococcus suis]
MKLEEFSVAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGRDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPCQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVDNLVDNLRELESEKLFDQIQIYQRDKTCVYDSETDEGSAAEVLQECLFGKWNKVEEEML
KVGQERLRELCNRDREENYENKKN

Nucleotide

• Length: 795 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18301.73 Da
• Isoelectric Point: 4.3971

>AT288921 WP_074391383.1 NZ_LR738724:236836-237312 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYIDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDETNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp