Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1627257..1627931 Replicon chromosome
Accession NZ_LR738723
Organism Streptococcus suis isolate GD-0088

Toxin (Protein)


Gene name hicA Uniprot ID A0A123U128
Locus tag GPW68_RS08165 Protein ID WP_009910449.1
Coordinates 1627257..1627439 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A123TH46
Locus tag GPW68_RS08170 Protein ID WP_023371005.1
Coordinates 1627479..1627931 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1617304..1631004 13700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6681.93 Da        Isoelectric Point: 10.8207

>T288918 WP_009910449.1 NZ_LR738723:1627257-1627439 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKVGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16685.68 Da        Isoelectric Point: 4.0098

>AT288918 WP_023371005.1 NZ_LR738723:1627479-1627931 [Streptococcus suis]
MLVTYPALFYYDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A123U128

Antitoxin

Source ID Structure
AlphaFold DB A0A123TH46

References