Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1549440..1549923 Replicon chromosome
Accession NZ_LR738723
Organism Streptococcus suis isolate GD-0088

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag GPW68_RS07715 Protein ID WP_012027435.1
Coordinates 1549440..1549700 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag GPW68_RS07720 Protein ID WP_012775256.1
Coordinates 1549702..1549923 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW68_RS07690 1544825..1546054 - 1230 WP_023370895.1 tetratricopeptide repeat protein -
GPW68_RS07695 1546044..1547210 - 1167 WP_012775254.1 AI-2E family transporter -
GPW68_RS07700 1547346..1548350 + 1005 WP_023370897.1 lactonase family protein -
GPW68_RS07705 1548414..1548599 + 186 WP_002935693.1 hypothetical protein -
GPW68_RS07710 1548632..1549273 - 642 WP_023370899.1 HAD family hydrolase -
GPW68_RS07715 1549440..1549700 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW68_RS07720 1549702..1549923 - 222 WP_012775256.1 hypothetical protein Antitoxin
GPW68_RS07725 1550233..1551540 - 1308 WP_002935704.1 phosphopyruvate hydratase -
GPW68_RS07730 1551690..1552142 + 453 WP_024383805.1 DUF1694 domain-containing protein -
GPW68_RS07735 1552149..1552379 - 231 WP_023370903.1 hypothetical protein -
GPW68_RS07740 1552370..1553497 - 1128 WP_023370905.1 glycerate kinase -
GPW68_RS07745 1553605..1554255 + 651 WP_023370907.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1554691..1555893 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T288917 WP_012027435.1 NZ_LR738723:c1549700-1549440 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT288917 WP_012775256.1 NZ_LR738723:c1549923-1549702 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References