Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1403585..1404071 Replicon chromosome
Accession NZ_LR738723
Organism Streptococcus suis isolate GD-0088

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag GPW68_RS06995 Protein ID WP_011922754.1
Coordinates 1403585..1403854 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag GPW68_RS07000 Protein ID WP_002938604.1
Coordinates 1403844..1404071 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW68_RS06970 1399414..1400388 - 975 WP_024383695.1 YvcK family protein -
GPW68_RS06975 1400385..1401272 - 888 WP_002937261.1 RNase adapter RapZ -
GPW68_RS06980 1401294..1401671 - 378 WP_002937263.1 RidA family protein -
GPW68_RS06985 1401855..1403179 - 1325 Protein_1307 MATE family efflux transporter -
GPW68_RS06995 1403585..1403854 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW68_RS07000 1403844..1404071 - 228 WP_002938604.1 hypothetical protein Antitoxin
GPW68_RS07005 1404343..1405689 - 1347 WP_074389302.1 asparagine--tRNA ligase -
GPW68_RS07010 1405704..1406885 - 1182 WP_024383693.1 pyridoxal phosphate-dependent aminotransferase -
GPW68_RS07015 1406882..1407379 - 498 WP_024405519.1 DUF5590 domain-containing protein -
GPW68_RS07020 1407682..1408131 + 450 WP_024383028.1 MarR family transcriptional regulator -
GPW68_RS07025 1408194..1408739 + 546 WP_002941732.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T288916 WP_011922754.1 NZ_LR738723:c1403854-1403585 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT288916 WP_002938604.1 NZ_LR738723:c1404071-1403844 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References