Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1136965..1137466 Replicon chromosome
Accession NZ_LR738723
Organism Streptococcus suis isolate GD-0088

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag GPW68_RS05755 Protein ID WP_024405694.1
Coordinates 1137200..1137466 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag GPW68_RS05750 Protein ID WP_012775104.1
Coordinates 1136965..1137216 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW68_RS05725 1132293..1133459 + 1167 WP_011922414.1 carbamoyl phosphate synthase large subunit -
GPW68_RS05730 1133599..1133739 + 141 WP_012775106.1 hypothetical protein -
GPW68_RS05735 1133752..1134129 + 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
GPW68_RS05740 1134150..1134902 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
GPW68_RS05745 1134903..1136873 + 1971 WP_024405693.1 FtsX-like permease family protein -
GPW68_RS05750 1136965..1137216 + 252 WP_012775104.1 hypothetical protein Antitoxin
GPW68_RS05755 1137200..1137466 + 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW68_RS05760 1137508..1138173 + 666 WP_024405695.1 response regulator transcription factor -
GPW68_RS05765 1138170..1139111 + 942 WP_024405696.1 sensor histidine kinase -
GPW68_RS05770 1139186..1140694 + 1509 WP_024405697.1 phosphoglucomutase -
GPW68_RS05775 1140764..1141834 - 1071 WP_024405698.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T288915 WP_024405694.1 NZ_LR738723:1137200-1137466 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT288915 WP_012775104.1 NZ_LR738723:1136965-1137216 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References