288914

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1954693..1955299 Replicon chromosome
Accession NZ_LR738722
Organism Streptococcus suis isolate 861160

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag STREPSUIS_RS09725 Protein ID WP_012775364.1
Coordinates 1954693..1955022 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag STREPSUIS_RS09730 Protein ID WP_012028535.1
Coordinates 1955012..1955299 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STREPSUIS_RS09695 1951548..1952021 - 474 WP_024378560.1 IS200/IS605 family transposase -
STREPSUIS_RS09700 1952201..1953073 - 873 WP_024387385.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
STREPSUIS_RS09705 1953092..1953622 - 531 WP_074390182.1 DUF1697 domain-containing protein -
STREPSUIS_RS09710 1953636..1953893 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
STREPSUIS_RS09715 1953895..1954155 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
STREPSUIS_RS09720 1954231..1954686 - 456 WP_074390181.1 8-oxo-dGTP diphosphatase -
STREPSUIS_RS09725 1954693..1955022 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
STREPSUIS_RS09730 1955012..1955299 - 288 WP_012028535.1 hypothetical protein Antitoxin
STREPSUIS_RS09735 1955397..1955765 - 369 WP_012775453.1 hypothetical protein -
STREPSUIS_RS09740 1955758..1956327 - 570 WP_012775700.1 ribonuclease M5 -
STREPSUIS_RS09745 1956311..1957093 - 783 WP_012028536.1 TatD family hydrolase -
STREPSUIS_RS09750 1957200..1957337 - 138 WP_002939016.1 50S ribosomal protein L34 -
STREPSUIS_RS09755 1957505..1958500 - 996 WP_012775367.1 protein jag -
STREPSUIS_RS09760 1958520..1959332 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
STREPSUIS_RS09765 1959316..1959675 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1930213..1957093 26880
- flank IS/Tn - - 1951548..1952021 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T288914 WP_012775364.1 NZ_LR738722:c1955022-1954693 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT288914 WP_012028535.1 NZ_LR738722:c1955299-1955012 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References