Detailed information of TA system TA288910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 769071..770323
• Replicon: chromosome
• Accession: NZ_LR738722
• Organism: Streptococcus suis isolate 861160

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: STREPSUIS_RS04030
• Protein ID: WP_024405541.1
• Coordinates: 769547..770323 (+)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: STREPSUIS_RS04025
• Protein ID: WP_024405542.1
• Coordinates: 769071..769547 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STREPSUIS_RS04000	766240..766878	+	639	WP_074400613.1	peptidylprolyl isomerase	-
STREPSUIS_RS04005	766918..767994	+	1077	WP_074400614.1	toprim domain-containing protein	-
STREPSUIS_RS04010	768048..768275	+	228	WP_024418314.1	hypothetical protein	-
STREPSUIS_RS04015	768272..768661	+	390	WP_024405544.1	hypothetical protein	-
STREPSUIS_RS04020	768711..769001	+	291	WP_024405543.1	hypothetical protein	-
STREPSUIS_RS04025	769071..769547	+	477	WP_024405542.1	helix-turn-helix domain-containing protein	Antitoxin
STREPSUIS_RS04030	769547..770323	+	777	WP_024405541.1	zeta toxin family protein	Toxin
STREPSUIS_RS04035	770320..772380	+	2061	WP_074400615.1	AAA family ATPase	-
STREPSUIS_RS04040	772367..774181	+	1815	WP_024405539.1	ATP-dependent helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	neuB	682479..786337	103858

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (27-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29222.90 Da
• Isoelectric Point: 5.6995

>T288910 WP_024405541.1 NZ_LR738722:769547-770323 [Streptococcus suis]
MRLEEFSEEEFQKALQRTIRAQSRGKTIPNQPRAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQD
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQNCLFGKWSKVEEEML
KVGQERLGELVSANGEKK

Nucleotide

• Length: 777 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18303.70 Da
• Isoelectric Point: 4.3241

>AT288910 WP_024405542.1 NZ_LR738722:769071-769547 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHWVVA

Nucleotide

• Length: 477 bp