288909

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 740212..741644 Replicon chromosome
Accession NZ_LR738722
Organism Streptococcus suis isolate 861160

Toxin (Protein)


Gene name abiEi Uniprot ID -
Locus tag STREPSUIS_RS03910 Protein ID WP_074390209.1
Coordinates 740212..741057 (-) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID Q8DZ36
Locus tag STREPSUIS_RS03915 Protein ID WP_000037239.1
Coordinates 741054..741644 (-) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STREPSUIS_RS03905 737348..740149 + 2802 WP_074400605.1 CHAP domain-containing protein -
STREPSUIS_RS03910 740212..741057 - 846 WP_074390209.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
STREPSUIS_RS03915 741054..741644 - 591 WP_000037239.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - neuB 682479..786337 103858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32524.20 Da        Isoelectric Point: 5.2246

>T288909 WP_074390209.1 NZ_LR738722:c741057-740212 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFEKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRFITVLISINSD

Download         Length: 846 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23074.63 Da        Isoelectric Point: 7.8056

>AT288909 WP_000037239.1 NZ_LR738722:c741644-741054 [Streptococcus suis]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6Y8Q
AlphaFold DB A0A2I7ZET8

References