Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1037436..1037937 Replicon chromosome
Accession NZ_LR738720
Organism Streptococcus suis isolate GD-0001

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag GPW48_RS05385 Protein ID WP_024405694.1
Coordinates 1037436..1037702 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag GPW48_RS05390 Protein ID WP_012775104.1
Coordinates 1037686..1037937 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW48_RS05365 1033068..1034138 + 1071 WP_024405698.1 tyrosine recombinase XerS -
GPW48_RS05370 1034208..1035716 - 1509 WP_024405697.1 phosphoglucomutase -
GPW48_RS05375 1035791..1036732 - 942 WP_024405696.1 sensor histidine kinase -
GPW48_RS05380 1036729..1037394 - 666 WP_024405695.1 response regulator transcription factor -
GPW48_RS05385 1037436..1037702 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW48_RS05390 1037686..1037937 - 252 WP_012775104.1 hypothetical protein Antitoxin
GPW48_RS05395 1038029..1039999 - 1971 WP_024405693.1 FtsX-like permease family protein -
GPW48_RS05400 1040000..1040752 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
GPW48_RS05405 1040773..1041150 - 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
GPW48_RS05410 1041163..1041303 - 141 WP_012775106.1 hypothetical protein -
GPW48_RS05415 1041545..1042018 - 474 WP_024378560.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1041545..1042018 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T288900 WP_024405694.1 NZ_LR738720:c1037702-1037436 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT288900 WP_012775104.1 NZ_LR738720:c1037937-1037686 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References