Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 798118..798604 Replicon chromosome
Accession NZ_LR738720
Organism Streptococcus suis isolate GD-0001

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag GPW48_RS04240 Protein ID WP_011922754.1
Coordinates 798335..798604 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag GPW48_RS04235 Protein ID WP_002938604.1
Coordinates 798118..798345 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW48_RS04210 793451..793996 - 546 WP_002941732.1 NAD(P)H-dependent oxidoreductase -
GPW48_RS04215 794059..794508 - 450 WP_024383028.1 MarR family transcriptional regulator -
GPW48_RS04220 794810..795307 + 498 WP_024405519.1 DUF5590 domain-containing protein -
GPW48_RS04225 795304..796485 + 1182 WP_024383693.1 pyridoxal phosphate-dependent aminotransferase -
GPW48_RS04230 796500..797846 + 1347 WP_024405517.1 asparagine--tRNA ligase -
GPW48_RS04235 798118..798345 + 228 WP_002938604.1 hypothetical protein Antitoxin
GPW48_RS04240 798335..798604 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW48_RS04250 799010..800334 + 1325 Protein_774 MATE family efflux transporter -
GPW48_RS04255 800518..800895 + 378 WP_002937263.1 RidA family protein -
GPW48_RS04260 800917..801804 + 888 WP_074390194.1 RNase adapter RapZ -
GPW48_RS04265 801801..802775 + 975 WP_002937257.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T288899 WP_011922754.1 NZ_LR738720:798335-798604 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT288899 WP_002938604.1 NZ_LR738720:798118-798345 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References