Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sezT-pezT/zeta-couple_hipB |
| Location | 772504..773768 | Replicon | chromosome |
| Accession | NZ_LR738720 | ||
| Organism | Streptococcus suis isolate GD-0001 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | - |
| Locus tag | GPW48_RS04110 | Protein ID | WP_074390198.1 |
| Coordinates | 772980..773768 (+) | Length | 263 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | A0A0Z8GXZ9 |
| Locus tag | GPW48_RS04105 | Protein ID | WP_024415699.1 |
| Coordinates | 772504..772980 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW48_RS04060 | 767631..767952 | + | 322 | Protein_737 | DUF4368 domain-containing protein | - |
| GPW48_RS04065 | 767945..768904 | + | 960 | Protein_738 | hypothetical protein | - |
| GPW48_RS04070 | 768975..769274 | + | 300 | WP_024401832.1 | hypothetical protein | - |
| GPW48_RS04075 | 769288..769578 | + | 291 | WP_002935084.1 | hypothetical protein | - |
| GPW48_RS04080 | 769674..770312 | + | 639 | WP_002936427.1 | hypothetical protein | - |
| GPW48_RS04085 | 770351..771427 | + | 1077 | WP_074390201.1 | toprim domain-containing protein | - |
| GPW48_RS04090 | 771481..771708 | + | 228 | WP_000110921.1 | hypothetical protein | - |
| GPW48_RS04095 | 771705..772094 | + | 390 | WP_074390200.1 | chemotaxis protein | - |
| GPW48_RS04100 | 772144..772434 | + | 291 | WP_000667953.1 | hypothetical protein | - |
| GPW48_RS04105 | 772504..772980 | + | 477 | WP_024415699.1 | helix-turn-helix domain-containing protein | Antitoxin |
| GPW48_RS04110 | 772980..773768 | + | 789 | WP_074390198.1 | zeta toxin family protein | Toxin |
| GPW48_RS04115 | 773758..775512 | + | 1755 | WP_032458610.1 | AAA family ATPase | - |
| GPW48_RS04120 | 775505..777046 | + | 1542 | WP_024383488.1 | ATP-dependent helicase | - |
| GPW48_RS04125 | 777043..777635 | + | 593 | Protein_750 | hypothetical protein | - |
| GPW48_RS04130 | 777973..778335 | + | 363 | WP_000140674.1 | hypothetical protein | - |
| GPW48_RS04135 | 778338..778703 | + | 366 | WP_000431640.1 | plasmid mobilization relaxosome protein MobC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 263 a.a. Molecular weight: 29826.83 Da Isoelectric Point: 5.9824
>T288898 WP_074390198.1 NZ_LR738720:772980-773768 [Streptococcus suis]
MRLEEFSEVEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLTSKGYQVSLAIIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKDHHDGIVENLVDNLRELEREQLFDQIQIYQRDRACIYDSETDEGSAAEVLQDCLFGKCSKVEEEMM
KLGRERLVKLNNKNLLESNYGI
MRLEEFSEVEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLTSKGYQVSLAIIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKDHHDGIVENLVDNLRELEREQLFDQIQIYQRDRACIYDSETDEGSAAEVLQDCLFGKCSKVEEEMM
KLGRERLVKLNNKNLLESNYGI
Download Length: 789 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18243.69 Da Isoelectric Point: 4.4582
>AT288898 WP_024415699.1 NZ_LR738720:772504-772980 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQGIAFDDETNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQGIAFDDETNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|