Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1862361..1863163 Replicon chromosome
Accession NZ_LR735440
Organism Staphylococcus epidermidis strain none isolate Se_BPH0711

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GOZ26_RS09035 Protein ID WP_002439258.1
Coordinates 1862702..1863163 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GOZ26_RS09030 Protein ID WP_002439260.1
Coordinates 1862361..1862690 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ26_RS08995 1858109..1858639 + 531 WP_002439277.1 N-acetyltransferase -
GOZ26_RS09000 1858875..1859072 + 198 WP_002456096.1 hypothetical protein -
GOZ26_RS09005 1859465..1859698 - 234 Protein_1674 AAA family ATPase -
GOZ26_RS09010 1860073..1860396 + 324 WP_002456098.1 hypothetical protein -
GOZ26_RS09015 1860743..1861507 - 765 WP_002439267.1 phage regulatory protein/antirepressor Ant -
GOZ26_RS09020 1861557..1861763 + 207 WP_002439266.1 hypothetical protein -
GOZ26_RS12840 1861752..1861916 - 165 WP_002439265.1 hypothetical protein -
GOZ26_RS09025 1861913..1862167 - 255 WP_002439263.1 helix-turn-helix domain-containing protein -
GOZ26_RS09030 1862361..1862690 + 330 WP_002439260.1 helix-turn-helix domain-containing protein Antitoxin
GOZ26_RS09035 1862702..1863163 + 462 WP_002439258.1 ImmA/IrrE family metallo-endopeptidase Toxin
GOZ26_RS09040 1863179..1863697 + 519 WP_002439256.1 hypothetical protein -
GOZ26_RS09045 1863699..1864142 + 444 WP_002439254.1 hypothetical protein -
GOZ26_RS09050 1864215..1864409 + 195 WP_002439253.1 hypothetical protein -
GOZ26_RS09055 1864478..1864993 + 516 WP_002439252.1 hypothetical protein -
GOZ26_RS09060 1864995..1865330 + 336 WP_002439251.1 hypothetical protein -
GOZ26_RS09065 1865386..1865982 + 597 WP_002439250.1 phage integrase SAM-like domain-containing protein -
GOZ26_RS12845 1865986..1866450 + 465 Protein_1688 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1856564..1910252 53688


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(25-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18370.06 Da        Isoelectric Point: 6.8511

>T288893 WP_002439258.1 NZ_LR735440:1862702-1863163 [Staphylococcus epidermidis]
MGLYEKMLIKHDYIEVRETNVMPNDLHGLWLGDLILIKRNLSETRKAEVLYEELTHHKLTYGNILDQSKFNNRKFENYAR
RYGYENALPLRIIVEAHNYGISNLYELAEYVQLSEEYIVEILKHYKNKYGIGTHYGEYLITFDPLRVFKYKEI

Download         Length: 462 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12735.32 Da        Isoelectric Point: 5.7917

>AT288893 WP_002439260.1 NZ_LR735440:1862361-1862690 [Staphylococcus epidermidis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPKH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References