Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 888874..889383 Replicon chromosome
Accession NZ_LR735440
Organism Staphylococcus epidermidis strain none isolate Se_BPH0711

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag GOZ26_RS04380 Protein ID WP_001829980.1
Coordinates 889174..889383 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag GOZ26_RS04375 Protein ID WP_001829893.1
Coordinates 888874..889167 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ26_RS04350 883882..884670 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
GOZ26_RS04355 884676..885314 + 639 WP_002505076.1 thiamine phosphate synthase -
GOZ26_RS04360 885403..886275 + 873 WP_001832740.1 membrane protein insertase YidC -
GOZ26_RS04365 886381..887034 - 654 WP_001829983.1 HD domain-containing protein -
GOZ26_RS04370 887216..888700 - 1485 WP_001829964.1 cardiolipin synthase -
GOZ26_RS04375 888874..889167 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
GOZ26_RS04380 889174..889383 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
GOZ26_RS04385 889526..889663 + 138 WP_001829949.1 hypothetical protein -
GOZ26_RS04390 889763..890974 - 1212 WP_095694455.1 rod shape-determining protein RodA -
GOZ26_RS04395 891365..892438 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
GOZ26_RS04400 892450..893805 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T288890 WP_001829980.1 NZ_LR735440:889174-889383 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT288890 WP_001829893.1 NZ_LR735440:888874-889167 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References