Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 81378..81896 Replicon chromosome
Accession NZ_LR735440
Organism Staphylococcus epidermidis strain none isolate Se_BPH0711

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag GOZ26_RS00375 Protein ID WP_002437527.1
Coordinates 81378..81587 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1L8Y5R0
Locus tag GOZ26_RS00380 Protein ID WP_002437530.1
Coordinates 81603..81896 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ26_RS00360 77938..79140 - 1203 WP_002437522.1 restriction endonuclease subunit S -
GOZ26_RS00365 79130..80644 - 1515 WP_002437523.1 type I restriction-modification system subunit M -
GOZ26_RS00370 81128..81265 - 138 WP_002437525.1 hypothetical protein -
GOZ26_RS00375 81378..81587 - 210 WP_002437527.1 heavy-metal-associated domain-containing protein Toxin
GOZ26_RS00380 81603..81896 - 294 WP_002437530.1 copper-sensing transcriptional repressor CsoR Antitoxin
GOZ26_RS00385 82063..83577 + 1515 WP_032604342.1 cardiolipin synthase -
GOZ26_RS00390 83612..84259 + 648 WP_002437536.1 HD domain-containing protein -
GOZ26_RS00395 84537..86225 + 1689 WP_155978818.1 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside SCCmec mecA - 40286..113108 72822
- flank IS/Tn - - 84537..86225 1688


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-67)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7944.05 Da        Isoelectric Point: 4.1598

>T288889 WP_002437527.1 NZ_LR735440:c81587-81378 [Staphylococcus epidermidis]
MLNSNIVFIDNIETKEQAQMLNERLLNMIGVHTVSIDIERNMVNVEYETPTNLNSIEKEIYDAGFKVLS

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.84 Da        Isoelectric Point: 6.3270

>AT288889 WP_002437530.1 NZ_LR735440:c81896-81603 [Staphylococcus epidermidis]
MENQNHAHHSEQVKLNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLEHHMKSCIMEKINQGTE
EEAMEELLVTFQKLVKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5R0

References